業績 - 学術論文 >>> 学会発表

2011 - 2010	2009 - 2008	2007 - 2006	2005 - 2004

2009

1. M. Otsuka and I. Yamane, Prediction of Tablet Properties Based on Near Infrared Spectra of Raw Mixed Powders by Chemometrics: Scale-Up Factor of Blending and Tableting Processes, J. Pharm. Sci.;98(11):4296-305 (2009) .
2. M. Fujimoto, K. Mihara, J. A. Jorgenson , K. Otsuka, M. Aburada, T. Kawada, J. Ishizaki, K. Miyamoto, M. Otsuka, Effects of the Position of the Paddle Shaft on the Dissolution Rates of Sodium Diclofenac Tablets and the Equivalence Assessment of the Generic product, Dissol. Tech., 16(4), 29-34 (2009).
3. M. Otsuka, K. Ibe, Y. Tokudome, H. Ohshima, Nano- and Macro-Geometrical Structural Change of Caffeine and Theophylline Anhydrate Tablets during Hydration Process by using X-ray Computed Tomography，Colloids and Surfaces B: Biointerfaces, 73, 351–359 (2009).
4. H. Shinzawa, K. Awa, T. Okumura, S. Morita, M. Otsuka, Y. Ozaki, H. Sato, Raman Imaging Analysis of Pharmaceutical Tablets by Two-Dimensional (2D) Correlation Spectroscopy, Vibrational Spectroscopy, 51, 125-131 (2009).
5. Y. Tokudome, H. Ohshima, M. Otsuka, Non-invasive and Rapid Analysis for Observation of Internal Structure of Press-Coated Tablet using X-ray Computed Tomography, Drug Devel. Ind. Pharm., 35(6): 678-682 (2009).
6. Y. Tokudome, M. Otsuka, A. Ito, R. Z. LeGeros, Long-Term Therapeutic Effect of Novel Calcium Phosphate-based Compounds Injected in Ovariectomized Rats, J. Biomed. Mat. Res. Part B: Applied Biomaterials, 90(1):229-237　(2009).
7. Y. Mohri, Y. Sakata and M. Otsuka, Quantitative evaluation of glycyrrhizic acid that affects the product quality of Kakkonto extract, a traditional herbal medicine, by chemometrical NIR spectroscopic method, J. Near Infrared Spectrosc. 17, 89-100 (2009).
8. Y. Sakata, M. Otsuka, Evaluation of Relationship between Molecular Behaviour and Mechanical Srenght of Pullulan films, Int. J. Pharm., 374, 33-38 (2009),
9. M. Otsuka, Y. Fukui, K. Ozaki, Comparative Evaluation of Bioactivity of Crystalline Trypsin for Drying Process by Fourier-Transformed Infrared Spectroscopy, Colloids and Surfaces B: Biointerfaces, 69(2), 194-200 (2009).
10. H. Kakuda, T. Okada, M. Otsuka, K. Katsumoto, T. Hasegawa, Multivariate analysis of DSC-XRD simultaneous measurement data: A Study of Multistage Crystalline Structure Changes in a Linear Poly(ethylene imine) Thin Film, Analytical and Bioanalytical Chemistry, 393(1), 367-376 (2009).

2008

1. K. Shinsako, Y. Okui, Y. Matsuda, J. Kunimasa, M. Otsuka, Effects of Bead Size and Polymerization in PMMA Bone Cement on Vancomycin Release, Bio-Medical Mat. Eng., 18, 377-385 (2008).
2. K. Papangkorn, G. Yan, D. D. Heslop, K. Moribe, A. A. Baig, M. Otsuka, W. I. Higuchi, Influence of Crystallite Microstrain on Surface Complexes Governing the Metastable Equilibrium Solubility Behavior of Carbonated Apatites, J. Colloid and Interface Science, 320(1), 96-109, (2008).
3. K. Awa, T. Okumura, H. Shinzawa, M. Otsuka, Y. Ozaki, Self-Modeling Curve Resolution (SMCR) Analysis of Near-Infrared (NIR) Imaging Data of Pharmaceutical Tablets, Analytica Chimica Acta, 619, 81-86 (2008).
4. S. Kanou, K. Nishimura, M. Ichikawa, J. Yoshida, Y. Sakata, M. Otsuka, Effect of Dehydration and Urea on Stability of Homosulfamine in Solid States, Drug Dev. Ind. Pharm., 34, 771-780 (2008).
5. M. Suda, K. Takayama, M. Otsuka, An Accurate Quantitative Analysis of Polymorphic Content by Chemometric X-ray Powder Diffraction，Anal. Sci., 24, 549-557(2008).
6. M. Otsuka, A. Oshinbe, R. Z. LeGeros, Y. Tokudome, A. Ito, K. Otsuka, W. I. Higuchi, Efficacy of the Injectable Calcium Phosphate Ceramics Suspensions Containing Magnesium, Zinc and Fluoride on the Bone Mineral Deficiency in Ovariectomized Rats, J. Pharm. Sci., 97 (1), 421-432 (2008)．