業績 - 学術論文 >>> 学会発表

2011 - 2010	2009 - 2008	2007 - 2006	2005 - 2004

2012

1. M. Otsuka, K. Papangkorn, A. A. Baig, W. I. Higuchi, Chemometric Evaluation of Physicochemical Properties of Carbonated-Apatitic Preparations by FT-Infrared Spectroscopy, J. Biomed. Mat. Res.: Part A, 100A (2012) 2186-2193
2. M. Otsuka, J. Nishizawa, N. Fukura, T. Sasaki, Characterization of Poly-Amorphous Indomethacin by Terahertz Spectroscopy, J. Infrared, Milli. Terahertz Waves, 33 (2012) 953-962
3. Y. Tokudome, M. Otsuka, Possibility of alveolar bone promoting enhancement by using lipophilic and/or hydrophilic zinc related compounds in zinc-deficient osteoporosis rats, Biol. Pharm. Bull. 35 (2012) 1496-1501
4. H. Uchida, K. Eguchi, M. Otsuka, Effect of laser irradiation on the stability of a photo-sensitive active pharmaceutical ingredient by Raman microscopy, J. Pharm. Biol. Anal. 70 (2012) 259-264.
5. J. Peerapattana, K. Otsuka, M. Otsuka, Application of NIR spectroscopy for the quality control of mangosteen pericarp powder: Quantitative analysis of alpha-mangostin in mangosteen pericarp powder and capsule, J. Natural Med., (2012) available on-line
6. M. Otsuka, M. Kamei, Robust Calibration Models to Predict Antipyrine Content in Various Kinds of Packaged Hospital Powder Preparations by Using Near-Infrared Spectroscopy, Bio-Medical Mat. Eng., In press.
7. H. Abe, M. Otsuka, Comparison of physico-chemical characteristics among three pharmaceutical spherical carbon adsorbents, Colloid Surface B, 100 (2012) 90-94.
8. Tomoko Ito, Yoshiyuki Koyama, Makoto Otsuka, "DNA complex-releasing system by injectable self-setting apatite cement", J. Gene Med. 14 (2012) 251-261

2011

1. H. Uchida, M. Otsuka, Quantitative analysis of pseudopolymorphic transformation of imidafenacin by application of a novel combination of near-infrared spectroscopy and a humidity-controlled 96-well plate, J Pharmacy Pharmacology, J. Pharmacy Pharmacology, 63 (2011) 911-917.
2. T. Ito, K. Ibe, T. Uchino, H. Ohshima and M. Otsuka, Preparation of DNA/gold Nanoparticle Encapsulated in Calcium Phosphate, J. Drug Delivery, 2011 (2011) 64761.
3. Y. Hattori, M. Otsuka, NIR spectroscopic study of the dissolution process in pharmaceutical tablets, Vibrational Spectrosco. 57 (2011) 275-281.
4. M. Otsuka, R. Hirano, Bone Cell Activity Responsive Drug Release from Biodegradable Apatite/Collagen Nano-Composite Cements, - In-Vitro Dissolution Medium Responsive Vitamin K2 Release -, Colloids and Surfaces B: Biointerfaces, 85 (2011) 338-342.
5. H. Uchida, T. Yoshinaga, H. Mori, M. Otsuka, Application of a Novel Combination of Near-infrared Spectroscopy and Humidity Controlled 96-well Plate to the Characterization of the Polymorphism of Imidafenacin, J. Pharmacy Pharmacology, 62 (2010) 1526-1533.
6. Y. Tokudome, A. Ito, M. Otsuka, Effect of Zinc-containing β-tricalcium Phosphate Nano Particles Injection on Jawbone Mineral Density and Mechanical Strength of Osteoporosis Model Rats, Biological Phram. Bull., 34 (2011) 1215-1218.

2010

1. M. Otsuka, J. Nishizawa, J. Shibata, M. Ito, Quantitative Evaluation of Mefenamic Acid Polymorphs by Terahertz-Chemometrics, J. Pharm. Sci., 99(9):4048-53, 2010.
2. M. Otsuka, Y. Fukui, Determination of carbamazepine polymorphic contents in double-layered tablets by using transmittance- and reflectance-near-infrared spectroscopy involving chemometrics, Drug Devel. Ind. Pharm., 36(12) 1404-1412 (2010).
3. M． Fujimoto, K. Mihara, J. A. Jorgenson, K. Otsuka, M. Aburada, T. Kawada, J. Ishizaki, K. Miyamoto, M. Otsuka, Effects of the Position of the Paddle Shaft and Inclination of the Dissolution Apparatus on the Dissolution Rates of Carbamazepine Tablets and the Equivalence Assessment of Generic Drugs, Dissol. Tech., 17，36-44, 2010.
4. H. Hamada, H. Ohshima, A. Ito, W. I. Higuchi, M. Otsuka, Effect of Geometrical Structure on the Biodegradation of a Three-Dimensionally Perforated Porous Apatite/Collagen Composite Bone Cell Scaffold, Biological Phram. Bull., 33(7), 1228-1232 (2010).
5. E. Otsuka, H. Abe,　M. Aburada, M. Otsuka, Non-destructive Prediction of the Drug Content of an Aspirin Suppository by Near-Infrared Spectroscopy, Drug Devel. Ind. Pharm., 36(7):839-44 (2010).
6. M. Otsuka, H. Kinoshita, Quantitative Determination of Hydrate Content of Theophylline Powder by Chemometric X-ray Powder Diffraction Analysis, AAPS PharmSciTech,, 11(1), 204-211 (2010).
7. M. Otsuka, H. Nakagawa, A. Ito, W. I. Higuchi, Effect of Geometrical Structure on Drug Release Rate of a Three-Dimensionally Perforated Porous Apatite/Collagen Composite Cement, J. Pharm. Sci., 99(1), 286-292 (2010).
8. M. Sakurai , H. Abe, N. Okamura, Y. Inoue, T. Akiyoshi, K. Matsuyama, T. Uchida, M. Otsuka, Stability of Gabexate Mesilate products: Influence of the Addition of Mannitol, Biomed. Mat. Eng., 20, 13-20 (2010).
9. P. Laovachirasuwan, J. Peerapattana, V. Srijesdaruk, P. Chitropas, M. Otsuka, The Physicochemical Properties of a Spray Dried Glutinous Rice Starch Biopolymer, Colloids and Surfaces B: Biointerfaces, 78, 30–35　(2010).
10. Y. Obata, S. Utsumi, H. Watanabe, M. Suda, Y. Tokudome,　M. Otsuka, K. Takayama, Infrared spectroscopic study of lipid interaction in stratum corneum treated with transdermal absorption enhancers, Inter. J. Pharmaceutics, 389, 18–23 (2010).
11. T. Uchino, M. Kamitakahara, M. Otsuka, C. Ohtsuki, Hydroxyapatite-forming capability and mechanical properties of organic-inorganic hybrids and a-tricalcium phosphate porous bodies, J. Ceramic Sco. Japan, 118(1), 57-61 (2010) .
12. Y. Fukui, M. Otsuka, Determination of the Crystallinity of Cephalexin in Pharmaceutical Formulations by Chemometrical Near-Infrared Spectroscopy, Drug Devel. Ind. Pharm., 36(1) 72-80 (2010).
13. M. Otsuka, M. Ishii, Improvement of Theophylline Anhydrate Stability at High-Humidity by Surface-Physicochemical Modification, Colloids and Surfaces B: Biointerfaces, 76, 158–163 (2010)
14. T. Ito, Y. Koyama, M. Otsuka, Analysis of the surface structure of DNA/polycation/hyaluronic acid ternary complex by Raman microscopy J. Pharm, Biomedical Anal., 51, 268–272 (2010).